Biguanelle ®
Isotonic Gynecological Solution, pH 4.0
Format:
Solution in 100 ml bottle, single-use.
Properties:
The use of Biguanelle ® helps restore natural physiological functions, even during traumatic
pharmacological or physical treatments. The use of Biguanelle ® during the treatment of vaginal
disorders or after physical treatment helps restore normal vaginal physiology. The product is
preserved with polyhexanide (PHMB), a cationic surfactant well tolerated by any mucosa.
Indications:
Treatment of vulvovaginitis and cervicovaginitis of any origin and nature by restoring and
maintaining o the natural physiology of the vaginal environment. Adjuvant in re-epithelialization
processes following physical treatment (diathermocoagulation, laser therapy, cryotherapy),
exerting a protective barrier effect on adult women.
Composition:
Polyhexamethylene biguanide hydrochloride (PHMB), Hydroxyethyl cellulose, Lactic acid, Glycerol,
Potassium chloride, Sodium edetate, Purified water
Features/Benefits:
1. Mono-dose, single-shot efficacy
2. Supported by 5 clinical trials
3. Wide spectrum of action (Bacteria, protozoa, fungi, viruses)
4. Protects the lactobacilli flora
5. High compliance and well-tolerated
6. 9 out of 10 women think Biguanelle® has a very convenient dosage (one-shot)
Dosage and method of administration:
One single application is sufficient, and can be repeated, if necessary, after 4 days as advised by a
doctor.
Packaging:
1 bottle of 100 ml with a vaginal cannula.
Instructions of use
1. Remove the sealed cap by pushing it to the side.
2. Remove the cannula from the protective packaging and insert it in the bottle making sure it is securely positioned.
3. Choose a suitable position which will allow the solution to stay inside the vagina when taking effect.
4. Carefully insert half the cannula into the vagina canal.
5. Squeeze the bottle until it is completely empty. Allow the liquid to remain in the vagina for a few minutes so the solution
can take effect. You should also follow any instructions given by your treating doctor.
Precautions for storage:
Store at room temperature (≤25°C), protected from light and in a cool place.
Βιβλιογραφία 1) Kaehn. Skin Pharmacol Physiol. 2010; 23 (suppl 1): 7–16 2) Sowlati-Hashjin et al. The Journal of Physical Chemistry B. 2020; 22: 4487–4497. 3) Gerli et
al. Eur Rev Med Pharmacol Sci 2003;7(5): 127-30. 4) Kovachev et al. Obstetrics and Gynecology 2016; Appendix 1, section II, Suppl 1 Pt 2, 55:11-5. 5) Biamonti et al.
Open Journal of Obstetrics and Gynecology, 2017; 7: 7-15. 6) Gentile et al. BMC Clinical Pathology 2012; 12: 17 7) Gincheva et al. IJMDAT 2020; 3: e220
Manufacturer INGE S.p.A. Via Garibaldi 190, 20024 S. Maria Rossa di Garbaagnate Milanese, Milan, Ιταλία.
Biguanelle® is a product of Lo.Li Pharma
Import/Distribution in Greece and Cyprus: GENOVA HEALTH IKE
Athens, 2 – 4 Leof. Mesogeion, 11527 – Tel.: 212 213 3017, www.genova.gr